A Mini Review on Discovery and Synthesis of Remdesivir as an Effective and Promising Drug against COVID-19

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a new human coronavirus has begun spreading over Wuhan City/China in December 2019, and then spread rapidly worldwide, causing pneumonia called COVID-19. Up to now, the scientists have extensively attempted to find effective vaccine...

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Published inRussian journal of bioorganic chemistry Vol. 47; no. 3; pp. 609 - 621
Main Authors Zarenezhad, E., Behrouz, S., Farjam, M., Rad, M. N. Soltani
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2021
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Coronaviruses
COVID-19
Disease transmission
Health services
Life Sciences
Mini Review
Nucleotides
Organic Chemistry
Severe acute respiratory syndrome coronavirus 2
Synthesis
Viral diseases
COVID-19
synthesis
coronavirus
SARS-CoV-2
remdesivir
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Summary:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as a new human coronavirus has begun spreading over Wuhan City/China in December 2019, and then spread rapidly worldwide, causing pneumonia called COVID-19. Up to now, the scientists have extensively attempted to find effective vaccines and drugs for treatment of coronavirus infections. To this end, various pharmaceutical agents are undergoing the clinical studies to assess their potency and efficacy against COVID-19. Based on the new findings, the U.S. food and drug administration (FDA) has issued an emergency use authorization for remdesivir as an effective anti-viral for remedying the hospitalized COVID-19 patients. Recently, the European medicines agency has authorized the use of remdesivir for the treatment of COVID-19. Remdesivir as a nucleotide prodrug exhibits broad-spectrum antiviral activities against RNA viruses. In this short review, we have rendered a brief overview of discovery and synthesis for remdesivir.
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ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162021030183