Quantum transport anomalies in DNA containing mispairs

The effect of mispairs on charge transport in DNA of sequence (GC)(TA)(N)(GC)(3) connected to platinum electrodes is studied using the tight-binding model. With parameters derived from an ab initio density functional result, we calculate the current versus bias voltage for DNA with and without a mis...

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Bibliographic Details
Published inNanotechnology Vol. 21; no. 48; p. 485101
Main Authors Wang, Xue-Feng, Chakraborty, Tapash, Berashevich, J
Format Journal Article
LanguageEnglish
Published England IOP Publishing 03.12.2010
Subjects
Base Pair Mismatch
Base Sequence
Biological Transport
DNA - chemistry
DNA - genetics
DNA - metabolism
Electrodes
Quantum Theory
Static Electricity
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Summary:The effect of mispairs on charge transport in DNA of sequence (GC)(TA)(N)(GC)(3) connected to platinum electrodes is studied using the tight-binding model. With parameters derived from an ab initio density functional result, we calculate the current versus bias voltage for DNA with and without a mispair and for different numbers of (TA) basepairs N between the single and triple (GC) basepairs. The current decays exponentially with N under low bias but reaches a minimum under high bias when a multichannel transport mechanism is established. A (GA) mispair substituting a (TA) basepair near the middle of the (TA)(N) sequence usually enhances the current by one order due to its low ionization energy but may decrease the current significantly when an established multichannel mechanism is broken.
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ISSN:0957-4484
1361-6528
DOI:10.1088/0957-4484/21/48/485101