Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts

• Published in: Journal of assisted reproduction and genetics Vol. 34; no. 6; pp. 775 - 779
• Main Authors: Reljič, Milan, Knez, Jure, Kovač, Vilma, Kovačič, Borut
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2017; Springer Nature B.V
• Subjects: Adult; Assisted Reproduction Technologies; Blastocyst - metabolism; Blastocyst - pathology; Embryo Implantation - physiology; Embryo Transfer; Embryos; Endometrium; Endometrium - injuries; Endometrium - physiopathology; Female; Fertilization in Vitro; Gynecology; Human Genetics; Humans; Implantation; In vitro fertilization; Medicine; Medicine & Public Health; Pregnancy; Pregnancy Rate; Prognosis; Reproductive Medicine; Sperm Injections, Intracytoplasmic; Stimulation; Local endometrial injury; Blastocyst transfer; Recurrent IVF failure
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-017-0916-4

Purpose The purpose of this study was to find out the most important prognostic factors for achieving a pregnancy after in vitro fertilization (IVF) in women with history of repeated unsuccessful IVF attempts. Methods We analyzed factors affecting pregnancy rate in a retrospective study including 429 IVF/ICSI cycles performed in women younger than 40 years with at least three previous consecutive failed IVF/ICSI attempts. Results Clinical pregnancy was observed in 140/429 (32.6%) cycles. Clinical pregnancy rate (CPR) was significantly higher in cycles with LEI compared to cycles without LEI before embryo transfer (44.4 vs 26.54%, p  = 0.007). The CPR was also higher in cycles with day 5 blastocyst- compared with day 3 cleavage-stage embryo transfers (45.51 vs 26.54%, p  < 0.001). In multivariate logistic regression model, only transfer of at least one good quality embryo (OR = 4.32, 95% CI 2.41–7.73), local endometrial injury (OR = 1.73, 95% CI 1.02–2.92), and transfer on day 5 (OR = 3.02, 95% CI 1.53–5.94) remained important independent prognostic factors for clinical pregnancy. Conclusions These results suggest that hysteroscopy with local injury to the endometrium prior to ovarian stimulation for IVF/ICSI can improve implantation and pregnancy rates in women experiencing recurrent IVF failure. However, large studies are needed to confirm these findings.