Thyroid Dysfunction in Neonates Born to Mothers Who Have Undergone Hysterosalpingography Involving an Oil-Soluble Iodinated Contrast Medium

• Published in: Hormone research in paediatrics Vol. 84; no. 6; pp. 370 - 375
• Main Authors: Satoh, Mari, Aso, Keiko, Katagiri, Yukiko
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2015
• Subjects: Congenital Hypothyroidism - blood; Congenital Hypothyroidism - etiology; Contrast Media - adverse effects; Ethiodized Oil - adverse effects; Female; Humans; Hysterosalpingography - adverse effects; Hysterosalpingography - methods; Infant, Newborn; Original Paper; Pregnancy; Thyroid Function Tests; Thyrotropin - blood; Hysterosalpingography; Hypothyroidism; Neonatal screening; Ethiodized oil; Iodine
• ISSN: 1663-2818; 1663-2826
• DOI: 10.1159/000439381

Background/Aims: Patients developing neonatal thyroid dysfunction following maternal hysterosalpingography (HSG) involving the use of oil-soluble iodinated contrast medium (ethiodized oil) have been reported. The present study aimed to investigate the frequency and risk factors for neonatal thyroid dysfunction following HSG. Methods: We studied 212 infants born to mothers who had become pregnant after undergoing HSG involving the use of ethiodized oil. Results: Five of the 212 infants tested positive during congenital hypothyroidism screening; this frequency (2.4%) was higher than the recall rate among first congenital hypothyroidism screening results (0.7%) in Tokyo, Japan. Two of the 5 screening-positive infants showed hypothyroidism, and 3 showed hyperthyrotropinemia. The urinary iodine concentrations in 4 out of the 5 screening-positive infants were 1,150, 940, 1,570, and 319 μg/l. The subjects were divided into thyroid dysfunction (n = 5) and normal thyroid function (n = 207) groups. The median dosage of ethiodized oil in the thyroid dysfunction group was significantly higher than in the normal thyroid function group (20 vs. 8 ml, p = 0.033). Conclusion: When infertile women undergo HSG, the dosage of oil-soluble iodinated contrast medium should be as low as possible to minimize the risk of fetal or neonatal thyroid dysfunction.