The association between body size, prostate volume and prostate-specific antigen

• Published in: Prostate cancer and prostatic diseases Vol. 10; no. 2; pp. 137 - 142
• Main Authors: Fowke, J H, Motley, S S, Cookson, M S, Concepcion, R, Chang, S S, Wills, M L, Smith, Jr, J A
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2007
• Subjects: Abdomen - anatomy & histology; Adult; Aged; Aged, 80 and over; Antigens; Biopsy; Body mass; Body Mass Index; Body Size; Diagnosis; Health aspects; Hip; Humans; Male; Middle Aged; Obesity; Physiological aspects; Prostate - anatomy & histology; Prostate cancer; Prostate-specific antigen; Prostate-Specific Antigen - analysis; Prostatic Hyperplasia - pathology; Prostatic intraepithelial neoplasia; Risk factors; Urinary tract; Waist-Hip Ratio; United States
• ISSN: 1365-7852; 1476-5608
• DOI: 10.1038/sj.pcan.4500924

Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume..