Assembly and trafficking of nicotinic acetylcholine receptors (Review)

Nicotinic acetylcholine receptors (nAChRs) are members of an extensive super-family of neurotransmitter-gated ion channels. In humans, nAChRs are expressed within the nervous system and at the neuromuscular junction and are important targets for pharmaceutical drug discovery. They are also the site...

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Bibliographic Details
Published inMolecular membrane biology Vol. 25; no. 4; pp. 279 - 292
Main Authors Millar, Neil S., Harkness, Patricia C.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2008
Taylor & Francis
Subjects
acetylcholine receptor
Animals
assembly
Molecular Chaperones - metabolism
Nicotinic receptor
Protein Folding
Protein Subunits - chemistry
Protein Subunits - metabolism
Protein Transport
Receptors, Nicotinic - chemistry
Receptors, Nicotinic - genetics
Receptors, Nicotinic - metabolism
trafficking
Up-Regulation
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Summary:Nicotinic acetylcholine receptors (nAChRs) are members of an extensive super-family of neurotransmitter-gated ion channels. In humans, nAChRs are expressed within the nervous system and at the neuromuscular junction and are important targets for pharmaceutical drug discovery. They are also the site of action for neuroactive pesticides in insects and other invertebrates. Nicotinic receptors are complex pentameric transmembrane proteins which are assembled from a large family of subunits; seventeen nAChR subunits ( 1- 10, 1- 4, , and ) have been identified in vertebrate species. This review will discuss nAChR subunit diversity and factors influencing receptor assembly and trafficking.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0968-7688
1464-5203
DOI:10.1080/09687680802035675