Preoperatively estimated graft flow rate contributes to the improvement of hemodynamics in revascularization for Moyamoya disease

• Published in: Journal of stroke and cerebrovascular diseases Vol. 30; no. 1; p. 105450
• Main Authors: Kuribara, Tomoyoshi, Mikami, Takeshi, Komatsu, Katsuya, Kimura, Yusuke, Kim, Sangnyon, Miyata, Kei, Akiyama, Yukinori, Enatsu, Rei, Hirano, Toru, Mikuni, Nobuhiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021
• Subjects: Adolescent; Adult; Blood Flow Velocity; Cerebral Angiography; Cerebral Revascularization - adverse effects; Cerebrovascular Circulation; Child; Child, Preschool; Computational fluid dynamics; Computed Tomography Angiography; Computed tomography perfusion; Female; Hemodynamics; Humans; Hydrodynamics; Male; Mean transit time; Middle Aged; Middle Cerebral Artery - diagnostic imaging; Middle Cerebral Artery - physiopathology; Middle Cerebral Artery - surgery; Models, Cardiovascular; Moyamoya disease; Moyamoya Disease - diagnostic imaging; Moyamoya Disease - physiopathology; Moyamoya Disease - surgery; Patient-Specific Modeling; Perfusion Imaging; Predictive Value of Tests; Retrospective Studies; Temporal Arteries - diagnostic imaging; Temporal Arteries - physiopathology; Temporal Arteries - surgery; Treatment Outcome; Young Adult; Computed tomography angiography; Mean transit time; Moyamoya disease; Computed tomography perfusion; Computational fluid dynamics
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2020.105450

lThe influence of the graft in bypass surgery was evaluated using CFD analysis.lThe flow rate of the graft contributed to the improvements of hemodynamic changes.lThe size of the graft was important in postoperative hemodynamic improvements. Objectives: Superficial temporal artery (STA)-middle cerebral artery (MCA) bypass operation is an effective treatment for patients with Moyamoya disease, and the hemodynamic parameters are reported to be improved after operation. However, there is no report concerning hemodynamic changes from the viewpoint of the preoperative anatomical structure of grafts. In this study, we evaluated the correlation between the preoperatively estimated blood flow of the graft obtained through image-based computational fluid dynamics (CFD) analysis and the hemodynamic changes in the acute phase after revascularization. Materials and methods: A total of 30 hemispheric sides of 23 patients were examined. The blood flow, that is, flow rate (FR) of the STA branches that were anastomosed to the MCA was evaluated using CFD analysis based on computed tomography (CT) angiography imaging data. The correlations between the FR and the hemodynamic changes in the acute phase after revascularization obtained through CT perfusion were assessed. Results: The preoperatively estimated FR of the graft was moderately correlated with the changes in the mean transit time significantly and weakly correlated with those in the cerebral blood flow and cerebral blood volume. In addition, the FR was strongly correlated with age and the diameter of the STA from the origin to the bifurcation.Conclusion: The preoperatively estimated FR of the graft obtained through image-based CFD analysis contributed to the improvement of the mean transit time after revascularization. Because the FR of the graft was associated with the diameter of the STA, the size of the STA might be an important factor in postoperative hemodynamic changes. This might lead to the risk assessment of acute drastic hemodynamic changes as cerebral hyperperfusion, and consequently, better surgical outcomes might be expected.