Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study

• Published in: Diabetologia Vol. 62; no. 4; pp. 598 - 610
• Main Authors: Lowe, William L., Lowe, Lynn P., Kuang, Alan, Catalano, Patrick M., Nodzenski, Michael, Talbot, Octavious, Tam, Wing-Hung, Sacks, David A., McCance, David, Linder, Barbara, Lebenthal, Yael, Lawrence, Jean M., Lashley, Michele, Josefson, Jami L., Hamilton, Jill, Deerochanawong, Chaicharn, Clayton, Peter, Brickman, Wendy J., Dyer, Alan R., Scholtens, Denise M., Metzger, Boyd E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2019; Springer Nature B.V
• Subjects: Adipose tissue; Adiposity; Adult; Age; Blood Glucose - analysis; Body fat; Body Mass Index; Body weight; Child; Children; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes, Gestational - blood; Fasting; Female; Follow-Up Studies; Gestation; Gestational diabetes; Glucose; Glucose Tolerance Test; Health risk assessment; Human Physiology; Humans; Hyperglycemia; Hyperglycemia - blood; Internal Medicine; Laboratory testing; Male; Maternal Age; Medicine; Medicine & Public Health; Metabolic Diseases; Obesity; Overweight; Pediatric Obesity - physiopathology; Pregnancy; Pregnancy Complications; Pregnancy in Diabetics - blood; Pregnancy Outcome; Prenatal Exposure Delayed Effects - blood; Prenatal Exposure Delayed Effects - physiopathology; Skinfold thickness; Waist Circumference; Pregnancy; Childhood obesity; Glucose; Adiposity
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/s00125-018-4809-6

Aims/hypothesis Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, independent of maternal BMI, remain less clear. The objective was to examine associations of maternal glucose levels during pregnancy with childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. Methods The HAPO Study was an observational epidemiological international multi-ethnic investigation that established strong associations of glucose levels during pregnancy with multiple adverse perinatal outcomes. The HAPO Follow-up Study (HAPO FUS) included 4832 children from ten HAPO centres whose mothers had a 75 g OGTT at ~28 weeks gestation 10–14 years earlier, with glucose values blinded to participants and clinical caregivers. The primary outcome was child adiposity, including: (1) being overweight/obese according to sex- and age-specific cut-offs based on the International Obesity Task Force (IOTF) criteria; (2) IOTF-defined obesity only; and (3) measurements >85th percentile for sum of skinfolds, waist circumference and per cent body fat. Primary predictors were maternal OGTT and HbA 1c values during pregnancy. Results Fully adjusted models that included maternal BMI at pregnancy OGTT indicated positive associations between maternal glucose predictors and child adiposity outcomes. For one SD difference in pregnancy glucose and HbA 1c measures, ORs for each child adiposity outcome were in the range of 1.05–1.16 for maternal fasting glucose, 1.11–1.19 for 1 h glucose, 1.09–1.21 for 2 h glucose and 1.12–1.21 for HbA 1c . Associations were significant, except for associations of maternal fasting glucose with offspring being overweight/obese or having waist circumference >85th percentile. Linearity was confirmed in all adjusted models. Exploratory sex-specific analyses indicated generally consistent associations for boys and girls. Conclusions/interpretation Exposure to higher levels of glucose in utero is independently associated with childhood adiposity, including being overweight/obese, obesity, skinfold thickness, per cent body fat and waist circumference. Glucose levels less than those diagnostic of diabetes are associated with greater childhood adiposity; this may have implications for long-term metabolic health.