Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training

• Published in: International Journal of Obesity Vol. 42; no. 7; pp. 1366 - 1377
• Main Authors: He, Zihong, Rankinen, Tuomo, Leon, Arthur S., Skinner, James S., Tchernof, André, Bouchard, Claude
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2018; Nature Publishing Group
• Subjects: 631/443/319/2723; 692/499; 692/700/2817; Adipose tissue; Age composition; Age factors; Analysis; Body composition; Body fat; Body weight; Composition effects; Contraceptives; Correlation analysis; Dosage and administration; Epidemiology; Exercise; Family studies; Fat-free body mass; Globulins; Health aspects; Health Promotion and Disease Prevention; Hormones; Internal Medicine; Medicine; Medicine & Public Health; Men; Menopause; Metabolic Diseases; Obesity; Oral contraceptives; Overweight; Physical fitness; Physical training; Plasma levels; Progesterone; Public Health; Sex; Sex hormones; Steroid hormones; Steroids; Steroids (Drugs); Testosterone; Training; Women
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/s41366-018-0033-1

Background/objectives Plasma steroid hormone levels vary between men and women, but their associations with BMI and adiposity are controversial. Furthermore, little is known about the role of exercise programs on the relationship between steroid hormones and adiposity. This report evaluates these relationships for plasma levels of adrenal, gonadal, and conjugated steroids with body composition and fat distribution in sedentary men and women, aged 17–65 years, and their responses to an exercise program. Subjects/methods In the sedentary state, 270 men (29% Blacks) and 304 women (34% Blacks) from the HERITAGE Family Study were available. Among them, 242 men and 238 women completed a 20-week fully standardized exercise program. Fourteen steroid hormones and SHBG concentrations were assayed in a fasted state and were compared for their associations with adiposity in men and women and in response to the exercise program. Covariates adjusted for in partial correlation analysis were age, ancestry, menopause status (women), and oral contraceptives/hormone replacement treatment status (women) at baseline, as well as baseline value of the trait for the training response. Differences among normal weight, overweight, and obese subjects were also considered. Statistical significance was set at P  < 0.0001. Results Baseline levels of dihydrotesterone (DHT), 17 hydroxy progesterone (OHPROG), sex hormone-binding globulin (SHBG), and testosterone (TESTO) were negatively associated with fat mass and abdominal fat ( P  < 0.0001) in men and for SHBG in women ( P  < 0.0001). TESTO was not correlated with fat-free mass in men or women, but was significantly associated with % fat-free mass in men. No association was detected between baseline steroid hormone levels and changes in adiposity traits in response to 20 weeks of exercise. Conclusion In men, low DHT, OHPROG, SHBG, and TESTO were associated with higher adiposity and abdominal and visceral fat. A similar adiposity profile was observed in women with low SHBG.