Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before th...

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Published inFrontiers in aging neuroscience Vol. 13; p. 702231
Main Authors Wang, Cong-mei, Chen, Wei-can, Zhang, Yan, Lin, Shu, He, He-fan
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 08.07.2021
Frontiers Media S.A
Subjects
Anesthesia
Anesthetics
Animal models
Behavior
Biomarkers
Bone surgery
Brain research
Cognitive ability
combination therapy
Drug dosages
Executive function
Heart surgery
Inflammation
Memory
neuroinflammation
Neuroscience
neurotransmitter
Orthopedics
Patients
postoperative cognitive dysfunction
Proteins
Sevoflurane
sevoflurane anesthesia
Tumor necrosis factor-TNF
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Summary:Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Edited by: Sara Palermo, Carlo Besta Neurological Institute (IRCCS), Italy
Reviewed by: Selvinaz Yakan, Ağrı İbrahim Çeçen University, Turkey; Cheng Zhou, Sichuan University, China
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.702231