Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss

Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of the auditory system. However, they are vulnerable to genetic defects, noise exposure, ototoxic drugs and aging, and loss or damage of HCs and SGNs results in permanent hearing loss due to their limited capacity...

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Published inFrontiers in cellular neuroscience Vol. 15; p. 760422
Main Authors Guo, Lingna, Cao, Wei, Niu, Yuguang, He, Shuangba, Chai, Renjie, Yang, Jianming
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 13.10.2021
Frontiers Media S.A
Subjects
Aging
Antioxidants
Apoptosis
Auditory system
Autophagy
Biosynthesis
Cochlea
Drugs
Gene therapy
Hair cells
Hearing loss
Homeostasis
Inner ear
Kinases
Mammals
mechanism
Neuroscience
Noise
Ototoxicity
Oxidative stress
Phagocytosis
Proteins
Regeneration
Spiral ganglion
spiral ganglion neurons
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Summary:Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of the auditory system. However, they are vulnerable to genetic defects, noise exposure, ototoxic drugs and aging, and loss or damage of HCs and SGNs results in permanent hearing loss due to their limited capacity for spontaneous regeneration in mammals. Many efforts have been made to combat hearing loss including cochlear implants, HC regeneration, gene therapy, and antioxidant drugs. Here we review the role of autophagy in sensorineural hearing loss and the potential targets related to autophagy for the treatment of hearing loss.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Reviewed by: Haiying Sun, Huazhong University of Science and Technology, China; Yu Sun, Huazhong University of Science and Technology, China
These authors have contributed equally to this work
This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience
Edited by: Zuhong He, Wuhan University, China
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2021.760422