Primary and isolated anaplastic large cell lymphoma of the bone marrow

Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made...

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Bibliographic Details
Published inLeukemia & lymphoma Vol. 46; no. 3; pp. 461 - 463
Main Authors Gudgin, E, Rashbass, J, Pulford, KJ, Erber, WN
Format Journal Article
LanguageEnglish
Published United States Informa UK Ltd 01.03.2005
Taylor & Francis
Subjects
Anaplastic large cell lymphoma
anaplastic lymphoma kinase (ALK)
bone marrow
Bone Marrow - pathology
Bone Marrow - ultrastructure
Fatal Outcome
hemophagocytosis
Humans
Immunohistochemistry
Lymphoma, Large-Cell, Anaplastic - pathology
Lymphoma, Large-Cell, Anaplastic - ultrastructure
Male
Middle Aged
pancytopenia
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Summary:Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoma in which the majority of patients present with advanced stage III or IV disease. Here we report a case of ALCL where bone marrow was the only site of disease, in a 60-year-old man with pyrexia and pancytopenia. The diagnosis of ALCL was made on detection of CD30-positive anaplastic cells in the bone marrow, together with prominent hemophagocytosis. Genetics confirmed the clonal nature of the disease and showed it to be anaplastic lymphoma kinase (ALK) negative. Primary isolated bone marrow ALCL should be considered in the diagnosis of pancytopenia associated with hemophagocytosis.
Bibliography:ObjectType-Case Study-2
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ISSN:1042-8194
1029-2403
DOI:10.1080/10428190400011468