Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro

• Published in: Bulletin of experimental biology and medicine Vol. 161; no. 1; pp. 175 - 178
• Main Authors: Lin’kova, N. S., Drobintseva, A. O., Orlova, O. A., Kuznetsova, E. P., Polyakova, V. O., Kvetnoy, I. M., Khavinson, V. Kh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2016; Springer; Springer Nature B.V
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Biomedical and Life Sciences; Biomedicine; Caspase 3 - metabolism; Cell Biology; Cell Proliferation - drug effects; Cells, Cultured; Cellular Senescence; Collagen; Dipeptides - pharmacology; Fibroblast growth factors; Fibroblasts - drug effects; Fibroblasts - physiology; Hyaluronic acid; Internal Medicine; Laboratory Medicine; Matrix Metalloproteinase 9 - metabolism; Oligopeptides - pharmacology; Pathology; Rats, Wistar; Skin; Skin care; Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine); skin; cell cultures; aging; signal molecules; short peptides
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3370-x

The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.