Genotypic and phenotypic heterogeneity in Streptococcus mutans isolated from diabetic patients in Rome, Italy

Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of the Streptococcus mutans isolated from type II diabetic patients (n = 25; age 42–68). Eighty-two percent of isolates were classified as serotype c . No serotype k was present...

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Published inSpringerPlus Vol. 5; no. 1; p. 1794
Main Authors De, Arpan, Pasquantonio, Guido, Cerroni, Loredana, Petrelli, Dezemona, Lauro, Davide, Longhi, Marta, Vitali, Luca A.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 13.10.2016
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
PFGE
Antimicrobial susceptibility
Caries
Plaque
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Summary:Our study focuses on the antimicrobial susceptibility, genotypic and phenotypic heterogeneity, and serotype classification of the Streptococcus mutans isolated from type II diabetic patients (n = 25; age 42–68). Eighty-two percent of isolates were classified as serotype c . No serotype k was present. Macrorestriction analysis of genomic DNA of the isolates exhibited a clonal diversity that paralleled the phenotypic heterogeneity, which was also assessed in terms of biofilm forming ability. Isolates were susceptible to all the classes of antibiotics. In conclusion a great heterogeneity and no antimicrobial resistance were apparent in the considered S. mutans strains from diabetic patients.
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ISSN:2193-1801
2193-1801
DOI:10.1186/s40064-016-3470-0