Energy-Period Profiles of Brain Networks in Group fMRI Resting-State Data: A Comparison of Empirical Mode Decomposition With the Short-Time Fourier Transform and the Discrete Wavelet Transform

• Published in: Frontiers in neuroscience Vol. 15; p. 663403
• Main Authors: Cordes, Dietmar, Kaleem, Muhammad F., Yang, Zhengshi, Zhuang, Xiaowei, Curran, Tim, Sreenivasan, Karthik R., Mishra, Virendra R., Nandy, Rajesh, Walsh, Ryan R.
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 21.05.2021; Frontiers Media S.A
• Subjects: Algorithms; Brain; Brain mapping; Clustering; Decomposition; EMD; empirical mode decomposition; Energy; Fourier analysis; Functional magnetic resonance imaging; group ICA; IMF; intrinsic mode function; Methods; Movement disorders; Neurodegenerative diseases; Neuroscience; Neurosciences; Noise; Parkinson's disease; resting-state fMRI; Time series; Wavelet transforms
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.663403

Traditionally, functional networks in resting-state data were investigated with linear Fourier and wavelet-related methods to characterize their frequency content by relying on pre-specified frequency bands. In this study, Empirical Mode Decomposition (EMD), an adaptive time-frequency method, is used to investigate the naturally occurring frequency bands of resting-state data obtained by Group Independent Component Analysis. Specifically, energy-period profiles of Intrinsic Mode Functions (IMFs) obtained by EMD are created and compared for different resting-state networks. These profiles have a characteristic distribution for many resting-state networks and are related to the frequency content of each network. A comparison with the linear Short-Time Fourier Transform (STFT) and the Maximal Overlap Discrete Wavelet Transform (MODWT) shows that EMD provides a more frequency-adaptive representation of different types of resting-state networks. Clustering of resting-state networks based on the energy-period profiles leads to clusters of resting-state networks that have a monotone relationship with frequency and energy. This relationship is strongest with EMD, intermediate with MODWT, and weakest with STFT. The identification of these relationships suggests that EMD has significant advantages in characterizing brain networks compared to STFT and MODWT. In a clinical application to early Parkinson’s disease (PD) vs. normal controls (NC), energy and period content were studied for several common resting-state networks. Compared to STFT and MODWT, EMD showed the largest differences in energy and period between PD and NC subjects. Using a support vector machine, EMD achieved the highest prediction accuracy in classifying NC and PD subjects among STFT, MODWT, and EMD.