Oxidative stress early in pregnancy and pregnancy outcome

• Published in: Free radical research Vol. 42; no. 10; pp. 841 - 848
• Main Authors: Peter Stein, T., Scholl, Theresa O., Schluter, Margaret D., Leskiw, Maria J., Chen, Xinhua, Spur, Bernd W., Rodriguez, Ana
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: 8-hydroxy-2-deoxyguanosine; Adult; Antioxidants - metabolism; Biomarkers - blood; Biomarkers - urine; Birth Weight; Congenital Abnormalities - metabolism; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; dietary antioxidants; Dinoprost - analogs & derivatives; Dinoprost - urine; DNA Damage; Female; Gestational Age; GPx; Humans; Infant, Newborn; isoprostane; Lipid Peroxidation; Male; Middle Aged; Oxidants - blood; Oxidative Stress; Pre-Eclampsia - metabolism; Pregnancy; Pregnancy Complications - metabolism; Pregnancy Outcome; Premature Birth - metabolism; Prospective Studies; SOD; Young Adult
• ISSN: 1071-5762; 1029-2470
• DOI: 10.1080/10715760802510069

The objectives of this study were to determine whether oxidative stress early in pregnancy influenced pregnancy outcome. A combination of assays were used for exogenous and endogenous anti-oxidants together with two well accepted biomarkers for oxidative stress, the urinary excretion of 8-iso-PGF2 (a biomarker marker for lipid oxidation, n=508) and 8-oxo-7,8 dihydro-2 deoxyguanosine (8-OHdG, a biomarker for DNA oxidation, n=487). The two biomarkers tracked different pregnancy outcomes. Isoprostanes were associated with an increased risk of pre-eclampsia and a decreased proportion of female births. In contrast, 8-OHdG tracked lower infant birthweight and shortened gestation duration. Birth defects were associated with low levels of 8-OHdG.