Elevated levels of lipoprotein(a) in women with preeclampsia
OBJECTIVE: We examined the hypothesis that lipoprotein(a) levels are elevated in preeclampsia and associated with severity of the disease. STUDY DESIGN: Plasma lipoprotein(a) levels were measured in 24 normal pregnant women, 18 mild, and 8 severe preeclamptic women using an enzyme-linked immunosorbe...
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Published in | American journal of obstetrics and gynecology Vol. 178; no. 1; pp. 146 - 149 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
Mosby, Inc
1998
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | OBJECTIVE: We examined the hypothesis that lipoprotein(a) levels are elevated in preeclampsia and associated with severity of the disease.
STUDY DESIGN: Plasma lipoprotein(a) levels were measured in 24 normal pregnant women, 18 mild, and 8 severe preeclamptic women using an enzyme-linked immunosorbent assay method. Kruskall-Wallis one-way analysis of variance was used to evaluate the difference in plasma lipoprotein(a) among different groups. The Mann-Whitney
U test was used to compare the differences between two groups.
RESULTS: The plasma lipoprotein(a) levels were increased in pregnant women with both severe preeclampsia (median 826.9 mg/L [interquartile range 590.7, 986.9 mg/L],
n = 8,
p < 0.0001) and mild preeclampsia (median 357.7 mg/L [interquartile range 208.0, 477.1 mg/L],
n = 18,
p < 0.0001) compared with normal pregnancy (median 78.5 mg/L [interquartile range 45.2, 127.9 mg/L],
n = 24). The lipoprotein(a) level was significantly higher in severe than in mild preeclampsia (
p < 0.001).
CONCLUSIONS: This study has demonstrated that lipoprotein(a) levels are elevated in preeclampsia and associated with severity of the disease. It may serve as a marker of the pathogenic process. (Am J Obstet Gynecol 1998;178:146-9.) |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9378 1097-6868 |
DOI: | 10.1016/S0002-9378(98)70642-8 |