Oligodendrocyte Development and Implication in Perinatal White Matter Injury
Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of...
Saved in:
Published in | Frontiers in cellular neuroscience Vol. 15; p. 764486 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Lausanne
Frontiers Research Foundation
04.11.2021
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Fuzheng Guo, University of California, Davis, United States This article was submitted to Non-Neuronal Cells, a section of the journal Frontiers in Cellular Neuroscience Reviewed by: Feng Mei, Army Medical University, China; Ben Emery, Oregon Health and Science University, United States |
ISSN: | 1662-5102 1662-5102 |
DOI: | 10.3389/fncel.2021.764486 |