Effect of Preparation Based on Trametes Pubescens Xylotroph Fungi on Lipid Peroxidation in the Blood of Experimental Animals under Conditions of Dark Stress

• Published in: Bulletin of experimental biology and medicine Vol. 162; no. 6; pp. 762 - 764
• Main Authors: Kolesnikova, L. I., Kolesnikov, S. I., Romanova, E. D., Chkhenkeli, V. A., Darenskaya, M. A., Grebenkina, L. A., Korytov, L. I., Bugun, O. V., Koroleva, N. V., Gutnik, I. N., Antonenko, F. F.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2017; Springer; Springer Nature B.V
• Subjects: alpha-Tocopherol - blood; Animals; Animals, Suckling; Antioxidants (Nutrients); Antioxidants - isolation & purification; Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Complex Mixtures - isolation & purification; Complex Mixtures - pharmacology; Darkness; Fungi; Glutathione; Glutathione - blood; Internal Medicine; Laboratory Medicine; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Oxidative Stress; Pathology; Stress, Physiological - drug effects; Superoxide dismutase; Superoxide Dismutase - blood; Superoxides; Swine; Trametes - chemistry; Vitamin A - blood; antioxidants; lipid peroxidation; dark stress
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-017-3707-0

Using the model of dark stress caused by animal maintenance at dimmed light we showed that Trametin (product obtained during liquid-phase culturing of Trametes pubescens xylotroph fungi) effectively prevented oxidative stress under conditions of light deprivation. The preparation increased the level of unsaturation of lipids, reduced the concentration of primary and end-products of LPO, and increases both the integral parameter of the antioxidant defense system (total antioxidant activity) and its components (activity of superoxide dismutase and reduced glutathione).