Unraveling the Potential of miRNAs from CSCs as an Emerging Clinical Tool for Breast Cancer Diagnosis and Prognosis

• Published in: International journal of molecular sciences Vol. 24; no. 21; p. 16010
• Main Authors: Nogueras Pérez, Raquel, Heredia-Nicolás, Noelia, de Lara-Peña, Laura, López de Andrés, Julia, Marchal, Juan Antonio, Jiménez, Gema, Griñán-Lisón, Carmen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Apoptosis; B cells; Biomarkers; Breast cancer; breast cancer stem cells; Cancer; Cancer therapies; Cell growth; Chemotherapy; Development and progression; Diagnosis; diagnostic; Enzymes; Gene expression; Genes; Genetic engineering; Genotype & phenotype; Homeostasis; Kinases; Metastasis; MicroRNA; MicroRNAs; miRNAs; Oncology, Experimental; Patients; Prognosis; prognostic; Proteins; Reproducibility; signature; Stem cells; Transplantation; Canada; Spain
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms242116010

Breast cancer (BC) is the most diagnosed cancer in women and the second most common cancer globally. Significant advances in BC research have led to improved early detection and effective therapies. One of the key challenges in BC is the presence of BC stem cells (BCSCs). This small subpopulation within the tumor possesses unique characteristics, including tumor-initiating capabilities, contributes to treatment resistance, and plays a role in cancer recurrence and metastasis. In recent years, microRNAs (miRNAs) have emerged as potential regulators of BCSCs, which can modulate gene expression and influence cellular processes like BCSCs’ self-renewal, differentiation, and tumor-promoting pathways. Understanding the miRNA signatures of BCSCs holds great promise for improving BC diagnosis and prognosis. By targeting BCSCs and their associated miRNAs, researchers aim to develop more effective and personalized treatment strategies that may offer better outcomes for BC patients, minimizing tumor recurrence and metastasis. In conclusion, the investigation of miRNAs as regulators of BCSCs opens new directions for advancing BC research through the use of bioinformatics and the development of innovative therapeutic approaches. This review summarizes the most recent and innovative studies and clinical trials on the role of BCSCs miRNAs as potential tools for early diagnosis, prognosis, and resistance.