The ESCRT Pathway

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these d...

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Published inDevelopmental cell Vol. 21; no. 1; pp. 77 - 91
Main Authors Henne, William M., Buchkovich, Nicholas J., Emr, Scott D.
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 19.07.2011
Cell Press
Subjects
abscission
Animals
biogenesis
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Endosomal Sorting Complexes Required for Transport - genetics
Endosomal Sorting Complexes Required for Transport - metabolism
Fundamental and applied biological sciences. Psychology
Humans
lysosomes
Molecular and cellular biology
Multivesicular Bodies - metabolism
proteins
sorting
vacuoles
Development
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Summary:Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.
Bibliography:ObjectType-Article-1
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ISSN:1534-5807
1878-1551
1878-1551
DOI:10.1016/j.devcel.2011.05.015