Use of connectotyping on task functional MRI data reveals dynamic network level cross talking during task performance

• Published in: Frontiers in neuroscience Vol. 16; p. 951907
• Main Authors: Vazquez-Trejo, Valeria, Nardos, Binyam, Schlaggar, Bradley L., Fair, Damien A., Miranda-Dominguez, Oscar
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 10.10.2022; Frontiers Media S.A
• Subjects: Brain; Brain mapping; cognition; Cognitive ability; connectotyping; Decision making; dynamic connectivity; fMRI; functional connectivity; Functional magnetic resonance imaging; Generalized linear models; Hemodynamics; Information processing; Mental task performance; Methods; Neural networks; Neuroscience; task fMRI; Within-subjects design
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2022.951907

Task-based functional MRI (fMRI) has greatly improved understanding of brain functioning, enabling the identification of brain areas associated with specific cognitive operations. Traditional analyses are limited to associating activation patterns in particular regions with specific cognitive operation, largely ignoring regional cross-talk or dynamic connectivity, which we propose is crucial for characterization of brain function in the context of task fMRI. We use connectotyping, which efficiently models functional brain connectivity to reveal the progression of temporal brain connectivity patterns in task fMRI. Connectotyping was employed on data from twenty-four participants (12 male, mean age 24.8 years, 2.57 std. dev) who performed a widely spaced event-related fMRI word vs. pseudoword decision task, where stimuli were presented every 20 s. After filtering for movement, we ended up with 15 participants that completed each trial and had enough usable data for our analyses. Connectivity matrices were calculated per participant across time for each stimuli type. A Repeated Measures ANOVA applied on the connectotypes was used to characterize differences across time for words and pseudowords. Our group level analyses found significantly different dynamic connectivity patterns during word vs. pseudoword processing between the Fronto-Parietal and Cingulo-Parietal Systems, areas involved in cognitive task control, memory retrieval, and semantic processing. Our findings support the presence of dynamic changes in functional connectivity during task execution and that such changes can be characterized using connectotyping but not with traditional Pearson’s correlations.