Identifying Risk and Resilience Factors in the Intergenerational Cycle of Maltreatment: Results From the TRANS-GEN Study Investigating the Effects of Maternal Attachment and Social Support on Child Attachment and Cardiovascular Stress Physiology

• Published in: Frontiers in human neuroscience Vol. 16; p. 890262
• Main Authors: Buchheim, Anna, Ziegenhain, Ute, Kindler, Heinz, Waller, Christiane, Gündel, Harald, Karabatsiakis, Alexander, Fegert, Jörg
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 18.07.2022; Frontiers Media S.A
• Subjects: adult attachment projective picture system; Adults; Arrhythmia; Attachment; attachment representation; Autonomic nervous system; Behavior; Caregivers; childhood maltreatment; Children; Children & youth; Cord blood; Domestic violence; Emotional abuse; Families & family life; Heart rate; Human Neuroscience; intergenerational cycle of attachment; Maternal behavior; maternal sensitivity; Mental health; Oxt gene; Oxytocin; Parents & parenting; Parturition; Respiration; Risk factors; Single-nucleotide polymorphism; Social interactions; Social support; Stress response
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2022.890262

Introduction Childhood maltreatment (CM) is a developmental risk factor and can negatively influence later psychological functioning, health, and development in the next generation. A comprehensive understanding of the biopsychosocial underpinnings of CM transmission would allow to identify protective factors that could disrupt the intergenerational CM risk cycle. This study examined the consequences of maternal CM and the effects of psychosocial and biological resilience factors on child attachment and stress-regulatory development using a prospective trans -disciplinary approach. Methods Mother-child dyads ( N = 158) participated shortly after parturition ( t 0 ), after 3 months ( t 1 ), and 12 months later ( t 2 ). Mothers’ CM experiences were assessed at t 0 , attachment representation at t 1 and psychosocial risk and social support were assessed at t 1 and t 2 . At t 2 , dyads participated in the Strange Situation Procedure (SSP). Children’s attachmen status were classified as organized vs. disorganized, including their level of disorganized behavior, and heart rate (HR) and respiratory sinus arrhythmia (RSA) were recorded as stress response measures of the autonomic nervous system. Maternal caregiving during SSP was assessed using the AMBIANCE scale. Child’s single nucleotide polymorphisms rs 2254298 within the oxytocin receptor (OXTR) and rs 2740210 of the oxytocin gene (OXT) were genotyped using DNA isolated from cord blood. Results Maternal CM experiences (CM+) were significantly associated with an unresolved attachment status, higher perceived stress and more psychological symptoms. These negative effects of CM were attenuated by social support. As expected, maternal unresolved attachment and child disorganized attachment were significantly associated. Maternal caregiving did not mediate the relationship between maternal and child attachment but influenced children’s HR and RSA response and disorganized behavior. Moreover, the rs 2254298 genotype of the OXTR gene moderated the stress response of children from mothers with CM. Children carrying the rs 2740210 risk allele of the OXT gene showed more disorganized behavior independent from maternal CM experiences. Conclusion We replicated and extended existing CM and attachment models by co-examining maternal attachment, social support, and child genetic susceptibility on child attachment and cardiovascular stress regulation. The findings contribute to an extended understanding of risk and resilience factors and enable professionals to target adequate services to parents and children at risk.