PACAP deficiency as a model of aging

Dysregulation of neuropeptides may play an important role in aging-induced impairments. In the long list of neuropeptides, pituitary adenylate cyclase–activating polypeptide (PACAP) represents a highly effective cytoprotective peptide that provides an endogenous control against a variety of tissue-d...

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Bibliographic Details
Published inGeroScience Vol. 40; no. 5-6; pp. 437 - 452
Main Authors Reglodi, D., Atlasz, T., Szabo, E., Jungling, A., Tamas, A., Juhasz, T., Fulop, B. D., Bardosi, A.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.12.2018
Springer Nature B.V
Subjects
Aging
Amyloidosis
Antioxidants
Apoptosis
Biomedical and Life Sciences
Cell Biology
Cornea
Degeneration
Geriatrics/Gerontology
Inflammation
Keratinization
Life Sciences
Mimicry
Molecular Medicine
Neuropeptides
Oxidative stress
Pituitary adenylate cyclase-activating polypeptide
Retina
Review
Review Article
Rodents
Aging
Amyloidosis
Degeneration
PACAP
Apoptosis
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Summary:Dysregulation of neuropeptides may play an important role in aging-induced impairments. In the long list of neuropeptides, pituitary adenylate cyclase–activating polypeptide (PACAP) represents a highly effective cytoprotective peptide that provides an endogenous control against a variety of tissue-damaging stimuli. PACAP has neuro- and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. As PACAP is also a part of the endogenous protective machinery, it can be hypothesized that the decreased protective effects in lack of endogenous PACAP would accelerate age-related degeneration and PACAP knockout mice would display age-related degenerative signs earlier. Recent results support this hypothesis showing that PACAP deficiency mimics aspects of age-related pathophysiological changes including increased neuronal vulnerability and systemic degeneration accompanied by increased apoptosis, oxidative stress, and inflammation. Decrease in PACAP expression has been shown in different species from invertebrates to humans. PACAP-deficient mice display numerous pathological alterations mimicking early aging, such as retinal changes, corneal keratinization and blurring, and systemic amyloidosis. In the present review, we summarize these findings and propose that PACAP deficiency could be a good model of premature aging.
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ISSN:2509-2715
2509-2723
DOI:10.1007/s11357-018-0045-8