Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity

White matter hyperintensity (WMH) is common in healthy adults in their 60s and can be seen as early as in their 30s and 40s. Alterations in the brain structural and functional profiles in adults with WMH have been repeatedly studied but with a focus on late-stage WMH. To date, structural and functio...

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Published inFrontiers in aging neuroscience Vol. 13; p. 715434
Main Authors Guan, Shuai, Kong, Xiangyu, Duan, Shifei, Ren, Qingguo, Huang, Zhaodi, Li, Ye, Wang, Wei, Gong, Gaolang, Meng, Xiangshui, Ma, Xiangxing
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 16.08.2021
Frontiers Media S.A
Subjects
Activities of daily living
Asymptomatic
Brain mapping
cerebral small vessel disease
cortical thickness
Data processing
diffusion tensor imaging
Disease
Functional magnetic resonance imaging
Magnetic resonance imaging
Medical imaging
Neuroimaging
Neuroscience
Pathogenesis
Scanners
Software
Structure-function relationships
Substantia alba
Substantia grisea
white matter hyperintensity
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Summary:White matter hyperintensity (WMH) is common in healthy adults in their 60s and can be seen as early as in their 30s and 40s. Alterations in the brain structural and functional profiles in adults with WMH have been repeatedly studied but with a focus on late-stage WMH. To date, structural and functional MRI profiles during the very early stage of WMH remain largely unexplored. To address this, we investigated multimodal MRI (structural, diffusion, and resting-state functional MRI) profiles of community-dwelling asymptomatic adults with very early-stage WMH relative to age-, sex-, and education-matched non-WMH controls. The comparative results showed significant age-related and age-independent changes in structural MRI-based morphometric measures and resting-state fMRI-based measures in a set of specific gray matter (GM) regions but no global white matter changes. The observed structural and functional anomalies in specific GM regions in community-dwelling asymptomatic adults with very early-stage WMH provide novel data regarding very early-stage WMH and enhance understanding of the pathogenesis of WMH.
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Reviewed by: Ali Golestani, University of Toronto, Canada; Qiang Xu, Nanjing University, China
Edited by: Bogdan O. Popescu, Carol Davila University of Medicine and Pharmacy, Romania
These authors have contributed equally to this work and share first authorship
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.715434