The biogenesis, biological functions and modification of Circular RNAs

Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circul...

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Published inExperimental and molecular pathology Vol. 131; p. 104861
Main Authors Liu, Sen, Guo, Xiang Yu, Shang, Qing Juan, Gao, Peng
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.06.2023
Subjects
Animals
Biogenesis
Biological functions
Circular RNAs
Humans
Modification
Protein Binding
RNA, Circular - genetics
Time Factors
Transcription, Genetic
Modification
Biological functions
Biogenesis
Circular RNAs
Online AccessGet full text
ISSN0014-4800
1096-0945
1096-0945
DOI10.1016/j.yexmp.2023.104861

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Summary:Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-transcriptional modification, can affect the translation, localization, and degradation of circular RNAs. Cutting-edge research into circular RNAs have benefitted from the development of high-throughput sequencing technology. Furthermore, the expansion of novel research methods has promoted progress into circular RNA research.
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ISSN:0014-4800
1096-0945
1096-0945
DOI:10.1016/j.yexmp.2023.104861