Organoids for the Study of Retinal Development and Developmental Abnormalities

The cumulative knowledge of retina development has been instrumental in the generation of retinal organoid systems from pluripotent stem cells; and these three-dimensional organoid models, in turn, have provided unprecedented opportunities for retinal research and translational applications, includi...

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Published inFrontiers in cellular neuroscience Vol. 15; p. 667880
Main Authors Vielle, Anne, Park, Yuna K., Secora, Conner, Vergara, M. Natalia
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 05.05.2021
Frontiers Media S.A
Subjects
Cell cycle
Cell division
Cellular Neuroscience
congenital abnormalities
development
Drug development
Fibroblasts
Growth factors
Organoids
Photoreceptors
Pluripotency
Retina
Stem cells
Transcription factors
Vertebrates
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Summary:The cumulative knowledge of retina development has been instrumental in the generation of retinal organoid systems from pluripotent stem cells; and these three-dimensional organoid models, in turn, have provided unprecedented opportunities for retinal research and translational applications, including the ability to model disease in a human setting and to apply these models to the development and validation of therapeutic drugs. In this review article, we examine how retinal organoids can also contribute to our understanding of retinal developmental mechanisms, how this knowledge can be applied to modeling developmental abnormalities, and highlight some of the avenues that remain to be explored.
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Reviewed by: Stephanie C. Joachim, Ruhr University Bochum, Germany; Igor O. Nasonkin, AIVITA Biomedical, Inc., United States; Gerrit Hilgen, Northumbria University, United Kingdom
Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience
Edited by: Lin Cheng, The University of Iowa, United States
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2021.667880