Role of Exosomes in Brain Diseases

Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the main...

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Published inFrontiers in cellular neuroscience Vol. 15; p. 743353
Main Authors Zhang, Nan, He, Fengling, Li, Ting, Chen, Jinzhi, Jiang, Liping, Ouyang, Xin-Ping, Zuo, Lielian
Format Journal Article
LanguageEnglish
Published Lausanne Frontiers Research Foundation 13.09.2021
Frontiers Media S.A
Subjects
Alzheimer's disease
Angiogenesis
Biomarkers
Brain diseases
cargo
Cell cycle
Cell growth
Cell interactions
Cellular Neuroscience
clinical treatment
Drug resistance
Exosomes
Hypoxia
Lipids
Metastasis
MicroRNAs
miRNA
miRNAs
Movement disorders
Nervous system
Neurodegenerative diseases
Parkinson's disease
Prognosis
Proteins
Radiation
Stem cells
Traumatic brain injury
Tumors
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Summary:Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.
Bibliography:ObjectType-Article-2
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Edited by: Giordano Lippi, The Scripps Research Institute, United States
Reviewed by: Chiara Porro, University of Foggia, Italy; Yvette Wooff, Australian National University, Australia
This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience
These authors have contributed equally to this work and share first authorship
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2021.743353