Current diagnostics and treatment of fibrosarcoma -perspectives for future therapeutic targets and strategies

• Published in: Oncotarget Vol. 8; no. 61; pp. 104638 - 104653
• Main Authors: Augsburger, Daniela, Nelson, Peter J, Kalinski, Thomas, Udelnow, Andrej, Knösel, Thomas, Hofstetter, Monika, Qin, Ji Wei, Wang, Yan, Gupta, Arvid Sen, Bonifatius, Susanne, Li, Minglun, Bruns, Christiane J, Zhao, Yue
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 28.11.2017
• Subjects: Review; matrix metalloproteinases (MMPs); tumor microenvironment; therapeutic resistance; fibrosarcoma
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.20136

Adult-type fibrosarcoma is a rare and highly aggressive subtype of soft tissue sarcomas. Due to the existence of other spindle-cell shaped sarcomas, its diagnosis is always one of exclusion. The likelihood of misdiagnoses between similar tumour entities is high, and often leads to inappropriate tumour treatment. We summarize here the main features of fibrosarcoma. When fibrosarcoma is appropriately diagnosed, the patient`s overall prognosis is generally quite poor. Fibrosarcoma is characterized by its low sensitivity towards radio- and chemotherapy as well as by its high rate of tumour recurrences. Thus it is important to identify new methods to improve treatment of this tumour entity. We discuss some promising new directions in fibrosarcoma research, specifically focusing on more effective targeting of the tumour microenvironment. Communication between tumour cells and their surrounding stromal tissue play a crucial role in cancer progression, invasion, metastasis and chemosensitivity. The therapeutic potential of targeting the tumour microenvironment is addressed.