Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

• Published in: Translational psychiatry Vol. 8; no. 1; pp. 141 - 8
• Main Authors: Sugimoto, Koichiro, Kakeda, Shingo, Watanabe, Keita, Katsuki, Asuka, Ueda, Issei, Igata, Natsuki, Igata, Ryohei, Abe, Osamu, Yoshimura, Reiji, Korogi, Yukunori
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group
• Subjects: 59/57; 631/378; 631/477/2811; 96/21; Adult; Aged; Anisotropy; Behavioral Sciences; Biological Psychology; Case-Control Studies; Corpus Callosum - pathology; Cytokines; Depressive Disorder, Major - blood; Depressive Disorder, Major - pathology; Diffusion Tensor Imaging; Female; Humans; Inflammation - complications; Interferon-gamma - blood; Interleukin-1beta - blood; Interleukin-6 - blood; Japan; Male; Medicine; Medicine & Public Health; Mental depression; Middle Aged; Neurosciences; Pharmacotherapy; Prospective Studies; Psychiatry; Review; Review Article; Severity of Illness Index; Tumor Necrosis Factor-alpha - blood; White Matter - pathology; Young Adult; Japan

Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-...