Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

• Published in: Translational psychiatry Vol. 8; no. 1; pp. 141 - 8
• Main Authors: Sugimoto, Koichiro, Kakeda, Shingo, Watanabe, Keita, Katsuki, Asuka, Ueda, Issei, Igata, Natsuki, Igata, Ryohei, Abe, Osamu, Yoshimura, Reiji, Korogi, Yukunori
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group
• Subjects: 59/57; 631/378; 631/477/2811; 96/21; Adult; Aged; Anisotropy; Behavioral Sciences; Biological Psychology; Case-Control Studies; Corpus Callosum - pathology; Cytokines; Depressive Disorder, Major - blood; Depressive Disorder, Major - pathology; Diffusion Tensor Imaging; Female; Humans; Inflammation - complications; Interferon-gamma - blood; Interleukin-1beta - blood; Interleukin-6 - blood; Japan; Male; Medicine; Medicine & Public Health; Mental depression; Middle Aged; Neurosciences; Pharmacotherapy; Prospective Studies; Psychiatry; Review; Review Article; Severity of Illness Index; Tumor Necrosis Factor-alpha - blood; White Matter - pathology; Young Adult; Japan
• ISSN: 2158-3188; 2158-3188
• DOI: 10.1038/s41398-018-0174-y

Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS ( p   <  0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels ( p   <  0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.