Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-...

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Published inTranslational psychiatry Vol. 8; no. 1; pp. 141 - 8
Main Authors Sugimoto, Koichiro, Kakeda, Shingo, Watanabe, Keita, Katsuki, Asuka, Ueda, Issei, Igata, Natsuki, Igata, Ryohei, Abe, Osamu, Yoshimura, Reiji, Korogi, Yukunori
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2018
Nature Publishing Group
Subjects
59/57
631/378
631/477/2811
96/21
Adult
Aged
Anisotropy
Behavioral Sciences
Biological Psychology
Case-Control Studies
Corpus Callosum - pathology
Cytokines
Depressive Disorder, Major - blood
Depressive Disorder, Major - pathology
Diffusion Tensor Imaging
Female
Humans
Inflammation - complications
Interferon-gamma - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Japan
Male
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Neurosciences
Pharmacotherapy
Prospective Studies
Psychiatry
Review
Review Article
Severity of Illness Index
Tumor Necrosis Factor-alpha - blood
White Matter - pathology
Young Adult
Japan
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Abstract Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS ( p   <  0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels ( p   <  0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
AbstractList Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS (p < 0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels (p < 0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS ( p   <  0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels ( p   <  0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS (p < 0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels (p < 0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS (p < 0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels (p < 0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
ArticleNumber 141
Author Igata, Ryohei
Ueda, Issei
Yoshimura, Reiji
Kakeda, Shingo
Watanabe, Keita
Igata, Natsuki
Abe, Osamu
Korogi, Yukunori
Sugimoto, Koichiro
Katsuki, Asuka
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Snippet Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the...
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SubjectTerms 59/57
631/378
631/477/2811
96/21
Adult
Aged
Anisotropy
Behavioral Sciences
Biological Psychology
Case-Control Studies
Corpus Callosum - pathology
Cytokines
Depressive Disorder, Major - blood
Depressive Disorder, Major - pathology
Diffusion Tensor Imaging
Female
Humans
Inflammation - complications
Interferon-gamma - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Japan
Male
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Neurosciences
Pharmacotherapy
Prospective Studies
Psychiatry
Review
Review Article
Severity of Illness Index
Tumor Necrosis Factor-alpha - blood
White Matter - pathology
Young Adult
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Title Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics
URI https://link.springer.com/article/10.1038/s41398-018-0174-y
https://www.ncbi.nlm.nih.gov/pubmed/30069019
https://www.proquest.com/docview/2081526452
https://www.proquest.com/docview/2082090286
https://pubmed.ncbi.nlm.nih.gov/PMC6070558
Volume 8
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