Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

• Published in: Nature (London) Vol. 577; no. 7790; pp. 410 - 415
• Main Authors: Song, Xinyang, Sun, Ximei, Oh, Sungwhan F., Wu, Meng, Zhang, Yanbo, Zheng, Wen, Geva-Zatorsky, Naama, Jupp, Ray, Mathis, Diane, Benoist, Christophe, Kasper, Dennis L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2020; Nature Publishing Group
• Subjects: 13/31; 38; 38/22; 38/23; 38/39; 38/61; 38/77; 38/90; 38/91; 45/41; 45/44; 631/250/347; 631/326/2565/547; 64; 64/60; Adaptive systems; Animals; Bacteria; Bile; Bile acids; Bile Acids and Salts - chemistry; Bile Acids and Salts - metabolism; Chemical synthesis; Cholesterol; Colitis; Colon; Diet; Digestive system; Duodenum; Energy balance; Energy metabolism; Foxp3 protein; G protein-coupled receptors; Gastrointestinal Microbiome; Gastrointestinal tract; Genomics; Hepatocytes; Homeostasis; Hormones; Humanities and Social Sciences; Immune system; Immunology; Inflammation; Innate immunity; Intestinal microflora; Intestine; Intestines - immunology; Intestines - microbiology; Lipid metabolism; Lipids; Lymphatic system; Lymphocytes; Lymphocytes T; Metabolic pathways; Metabolism; Metabolites; Mice, Inbred C57BL; Microbiomes; Microbiota; Microorganisms; multidisciplinary; Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics; Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology; Nuclear receptors; Population; Receptors; Restoration; Science; Science (multidisciplinary); Small intestine; Spleen; Symbionts; T-Lymphocytes, Regulatory - immunology; Transcription factors; Vitamins

The metabolic pathways encoded by the human gut microbiome constantly interact with host gene products through numerous bioactive molecules 1 . Primary bile acids (BAs) are synthesized within hepatocytes and released into the duodenum to facilitate absorption of lipids or fat-soluble vitamins 2 . So...