Circulating and Urinary microRNAs in Kidney Disease

microRNAs are small, noncoding RNAs that control gene/protein expression through target messengerRNA degradation and/or inhibition of protein synthesis. An array of experimental studies has shown the importance of microRNAs for disease initiation/progression. microRNAs are generally considered to ac...

Full description

Saved in:
Bibliographic Details
Published inClinical journal of the American Society of Nephrology Vol. 7; no. 9; pp. 1528 - 1533
Main Authors Lorenzen, Johan M, Thum, Thomas
Format Journal Article
LanguageEnglish
Published United States American Society of Nephrology 01.09.2012
Subjects
Animals
Gene Expression Regulation
Genetic Markers
Genetic Testing
Graft Rejection - genetics
Humans
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidney Diseases - genetics
Kidney Diseases - urine
Kidney Transplantation - adverse effects
MicroRNAs - blood
MicroRNAs - urine
Prognosis
RNA Stability
Online AccessGet full text

Cover

More Information
Summary:microRNAs are small, noncoding RNAs that control gene/protein expression through target messengerRNA degradation and/or inhibition of protein synthesis. An array of experimental studies has shown the importance of microRNAs for disease initiation/progression. microRNAs are generally considered to act as intracellular modulators of gene expression. However, first studies in the cancer and cardiovascular field have elucidated that microRNAs are remarkably stable in the extracellular compartment (e.g., in blood or urine). The detection and quantification of circulating microRNAs may, thus, represent a novel noninvasive tool to detect and monitor disease activity. In addition, there might be a potential biologic relevance of circulating microRNAs for cell/cell communication. The aim of the present article is to give an outline of recent work on circulating and urinary microRNAs as well as their potential paracrine activity in kidney disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.01170212