Perfluorooctanoic acid (PFOA) and perfluooctane sulfonate (PFOS) induce different modes of action in reproduction to Japanese medaka (Oryzias latipes)

• Published in: Journal of hazardous materials Vol. 368; pp. 97 - 103
• Main Authors: Kang, Jae Soon, Ahn, Tae-Gyu, Park, June-Woo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.04.2019
• Subjects: Choriogenin; Endocrine disruption; Fecundity; Fish; Vitellogenin; Endocrine disruption; Choriogenin; Fish; Vitellogenin; Fecundity
• ISSN: 0304-3894; 1873-3336
• DOI: 10.1016/j.jhazmat.2019.01.034

•PFOA and PFOS reduced egg production in fish.•PFOA and PFOS changed in transcription and protein levels of vitellogenin.•PFOA and PFOS have modes of estrogenic and anti-estrogenic actions in fish, respectively. Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have widely and frequently used in many industrial sectors, and thus have been frequently found in the environment. These chemicals may act as endocrine disrupting chemicals (EDCs), although the molecular mechanisms are still debated. In this study, Japanese medaka (Oryzias latipes) were exposed to 10 mg/l PFOA and 1 mg/l PFOS for 21 days, and the reproductive responses, such as the fecundity, secondary sexual characteristics and transcriptional levels of vitellogenin (vtg1 and vtg2) and choriogenin (chgh, chghm and chgl), were time-dependently evaluated (day 7, 14 and 21). PFOA and PFOS significantly reduced fecundity, and caused expression changes in the genes with time, although the patterns were different for each chemical and each sex. Different transcriptional regulations of vitellogenin and choriogenin in male suggest that PFOA and PFOS have different mode of actions in reproductive effects despite their similar chemical structure.