Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived Aspergillus sp

Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, of which sesquiterpenoids are an extremely important class of bioactive secondary metabolites. In this paper, we review the sources, chemical structures, bioactivity, biosynth...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 21; p. 7376
Main Authors Sun, Lixiang, Wang, Huannan, Yan, Maocai, Sai, Chunmei, Zhang, Zhen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 30.10.2022
MDPI
Subjects
Algae
Antibiotics
Antiinfectives and antibacterials
Aspergillus
Bacteria
bioactivity
Biochemistry
Biological activity
Biosynthesis
Chemical compounds
Corals
Drug development
E coli
Enzymes
Fungi
Inflammation
Lead compounds
Mangroves
marine fungi
Marine sediments
Metabolites
Microorganisms
Physiology
Review
Secondary metabolites
Sediments
Sesquiterpenoids
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Summary:Marine fungi Aspergillus sp. is an important source of natural active lead compounds with biological and chemical diversity, of which sesquiterpenoids are an extremely important class of bioactive secondary metabolites. In this paper, we review the sources, chemical structures, bioactivity, biosynthesis, and druggability evaluation of sesquiterpenoids discovered from marine fungi Aspergillus sp. since 2008. The Aspergillus species involved include mainly Aspergillus fumigatus, Aspergillus versicolor, Aspergillus flavus, Aspergillus ustus, Aspergillus sydowii, and so on, which originate from sponges, marine sediments, algae, mangroves, and corals. In recent years, 268 sesquiterpenoids were isolated from secondary metabolites of marine Aspergillus sp., 131 of which displayed bioactivities such as antitumor, antimicrobial, anti-inflammatory, and enzyme inhibitory activity. Furthermore, the main types of active sesquiterpenoids are bisabolanes, followed by drimanes, nitrobenzoyl, etc. Therefore, these novel sesquiterpenoids will provide a large number of potential lead compounds for the development of marine drugs.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27217376