Proliferation and Local Manifestations of Oxidative Stress in Mucous Membrane of the Ileum in Patients at Early Stages of Hemorrhagic Fever with Renal Syndrome

Activation of proliferative processes (Ki-67 proliferation index) and local oxidative stress was found in biopsy material from the mucosa of the large intestine of patients at the early stages of hemorrhagic fever with renal syndrome on days 5-10 after disease onset. Analysis of data of rectosigmoid...

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Published inBulletin of experimental biology and medicine Vol. 156; no. 3; pp. 320 - 322
Main Authors Martynenko, A. Yu, Timoshin, S. S., Fleishman, M. Yu, Lebed’ko, O. A.
Format Journal Article
LanguageEnglish
Published Boston Springer US 2014
Springer
Springer Nature B.V
Subjects
Adult
Biomedical and Life Sciences
Biomedicine
Cell Biology
Hemorrhagic fever
Hemorrhagic Fever with Renal Syndrome - metabolism
Humans
Ileum - metabolism
Internal Medicine
Intestinal Mucosa - metabolism
Laboratory Medicine
Oxidative Stress
Pathology
Ki-67 level
oxidative stress
hemorrhagic fever with renal syndrome
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Summary:Activation of proliferative processes (Ki-67 proliferation index) and local oxidative stress was found in biopsy material from the mucosa of the large intestine of patients at the early stages of hemorrhagic fever with renal syndrome on days 5-10 after disease onset. Analysis of data of rectosigmoidoscopy and clinical examination refl ected the presence of colitis. It can be suggested that activation of proliferation is typically associated with local oxidative stress during various pathological processes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2339-x