Evaluation of aglepristone and oxytocin on induction of parturition in guinea pig

• Published in: Veterinary medicine and science Vol. 9; no. 3; pp. 1297 - 1303
• Main Authors: Sara, Tayeban, Reza, Narenjisani, Morteza, Keywanloo, Vali, Yasamin, Soroori, Sarang, Ebrahim, Shahroozian
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2023; John Wiley and Sons Inc; Wiley
• Subjects: aglperistone; Animals; Birth weight; Body temperature; Body weight; Estrenes - pharmacology; Estrenes - therapeutic use; Female; Fetuses; guinea pig; Guinea Pigs; Heart rate; Hormones; induction of parturition; Mating; Neonates; Original; Oxytocin; Oxytocin - pharmacology; Parturition; Pregnancy; Progesterone; Progesterone receptors; Rabbits; RODENTS; Smooth muscle; Sodium chloride; Swine; Ultrasonic imaging; Ultrasonic transducers; Uterus; Vagina; guinea pig; induction of parturition; oxytocin; aglperistone
• ISSN: 2053-1095; 2053-1095
• DOI: 10.1002/vms3.1078

Background Induction of parturition in guinea pigs appears to be essential because these animals have a higher rate of reproductive problems than rabbits and small rodents. Objectives Since aglepristone (AGL) is a competitive progesterone antagonist acting through binding to progesterone receptors while oxytocin (OT) is a powerful constituent of uterine smooth muscle, the aim of this study was to evaluate the clinical and ultrasonographic impacts of AGL and OT on guinea pig parturition induction. Methods In this study, guinea pigs were allocated into five groups; each included five animals on the 61st day of pregnancy. In the aglepristone group (Agle), AGL was administrated subcutaneously (SC) once daily on 2 consecutive days (Days 61 and 62 post mating). Oxytocin (OT) was administered subcutaneously once and twice at 4‐h intervals on Day 62 post mating in oxytocin 1 (Oxy1) and oxytocin 2 (Oxy2) groups, respectively. The animals in the aglepristone‐oxytocin group (Agle‐Oxy) received AGL subcutaneously once daily on 2 consecutive days (Days 61 and 62 post mating) and OT on Day 62 post mating. The remaining sows received saline solution (0.9% NaCl) in the control group. Results According to the results, fetal heart rate, temperature, neonatal and maternal survival rates were not significantly different between the treatment and control groups (p > 0.05). Biparietal diameter of head and body weight of neonates in the Agle, Oxy2 and Agle‐Oxy groups showed a significant decline, compared to the control group (p < 0.05). The time interval between injection and delivery and the duration of pregnancy was significantly reduced in Agle, Oxy2, Agl‐Oxy groups, compared to the control and Oxy1 groups. Conclusions In conclusion, it seems that treatment Oxy2 can induce parturition in guinea pigs without side effects and lower pain during induction of parturition. In this study, the clinical and ultrasonographical evaluation of parturition induction in guinea pigs using oxytocin (OT) and aglepristone (AGL) was used in five different groups. The results showed that AGL and OT are able to successfully induce parturition in guinea pigs without side effects.