Quinidine does not affect the renal clearance of moxonidine

• Published in: British journal of clinical pharmacology Vol. 54; no. 3; pp. 251 - 254
• Main Authors: Wise, Stephen D., Chan, Clark, Schaefer, Hans G., He, Minxia M., Pouliquen, Isabelle J., Mitchell, Malcolm I.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2002; Blackwell Science Inc
• Subjects: Administration, Oral; Adult; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - pharmacokinetics; Cross-Over Studies; Drug Combinations; Drug Interactions; Humans; Imidazoles - administration & dosage; Imidazoles - pharmacokinetics; Kidney - metabolism; Male; Metabolic Clearance Rate; moxonidine; Pharmacokinetics; quinidine; Quinidine - administration & dosage; Quinidine - pharmacokinetics; renal; Time Factors
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1046/j.1365-2125.2002.01647.x

Aims To test the hypothesis that the renal clearance of moxonidine decreases when dosed with quinidine. Methods A randomized, two‐period study was conducted with six healthy, male subjects orally dosed with either 0.2 mg moxonidine alone or 1 h after 400 mg quinidine sulphate. Pharmacokinetic parameters were calculated using a noncompartmental analysis method. Results When coadministered, quinidine significantly increased moxonidine AUC and t1/2 by 11% and 15%, respectively, and decreased CL/F by 10% compared with the control dosing. CLR and Aeur were not significantly different. Clinically, both treatments were well tolerated. Conclusions Quinidine does not affect the renal clearance of moxonidine. The decrease  in  apparent  total  clearance  of  moxonidine  with  quinidine  coadministration was possibly due to metabolic inhibition, though not likely to be clinically significant.