In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride

• Published in: European journal of oral sciences Vol. 117; no. 1; pp. 58 - 63
• Main Authors: Altenburger, Markus J., Schirrmeister, Jörg F., Lussi, Adrian, Klasser, Manfred, Hellwig, Elmar
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2009
• Subjects: Adult; Animals; Cariostatic Agents - administration & dosage; Cattle; Cross-Over Studies; Dental Caries - prevention & control; Dental Enamel - drug effects; Dental Enamel - metabolism; Dentistry; Dose-Response Relationship, Drug; Double-Blind Method; enamel; Female; fluoride retention; Fluorides, Topical - administration & dosage; Fluorides, Topical - pharmacokinetics; Humans; in situ; Male; Middle Aged; remineralization; Tooth Remineralization - methods; Tooth, Artificial; Young Adult
• ISSN: 0909-8836; 1600-0722
• DOI: 10.1111/j.1600-0722.2008.00585.x

Limited information is available on the time‐dependent or dosage‐dependent cariostatic efficacy of highly concentrated fluoride compounds. This good clinical practice‐conforming, double‐blind, placebo‐controlled, crossover in situ study tested the hypothesis that a 1.0% amine fluoride fluid is superior to a 0.5% amine fluoride fluid regarding fluoride retention and mineral change in initial caries enamel lesions over a period of 28 d. Fluoride retention was significantly higher after application of the two fluoride fluids compared with placebo but had decreased in both groups to similar levels after only 1 wk. Mineral gain was significantly higher for both verum groups compared with placebo. The use of 1% fluoride fluid resulted in significantly higher remineralization compared with the use of 0.5% fluoride fluid. For both fluoride fluids mineral gain followed a linear relationship with time during the experimental period, indicating a possible further uptake of mineral, even after 4 wk.