Clinical features of asthma with connective tissue diseases
Background The clinical features of asthma with connective tissue diseases (CTDs) are not well‐known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs. Methods We retrospectively examined the records of adults (≥18 years old) with asthma followed up between...
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Published in | The clinical respiratory journal Vol. 17; no. 4; pp. 303 - 310 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.04.2023
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Background
The clinical features of asthma with connective tissue diseases (CTDs) are not well‐known. This study therefore aimed to investigate the clinical characteristics of asthma with CTDs.
Methods
We retrospectively examined the records of adults (≥18 years old) with asthma followed up between January 2010 and December 2019. We then compared the clinical features of asthma with and without CTDs.
Results
Among 568 subjects with asthma, 42 subjects (7.4%) had CTDs. The most frequent concomitant CTD was rheumatoid arthritis (n = 23, 54.8%), followed by systemic lupus erythematosus (n = 6, 14.3%). The proportion of women (with vs. without CTDs, 85.7% vs. 56.5%, p < 0.001) and Global Initiative for Asthma step were higher (Step 4 or 5, with vs. without CTDs, 81.0% vs. 62.0%, p = 0.01) in asthma with CTDs, whereas frequency of allergic rhinitis was higher in asthma without CTDs (with vs. without CTDs, 7.1% vs. 26.1%, p = 0.005). Eosinophil ratio (with vs. without CTDs, 2.1% vs. 3.5%, p = 0.009) and total immunoglobulin E level (with vs. without CTDs, 43 IU/mL vs. 237 IU/mL, p = 0.002) were lower in asthma with CTDs. In terms of lung function, percentage predicted forced vital capacity (with vs. without CTDs, 86.7% vs. 99.7%, p = 0.008) and percentage predicted forced expiratory volume in 1 s (%FEV1) (with vs. without CTDs, 77.2% vs. 88.4%, p = 0.02) were all lower in asthma with CTDs. With multivariable analysis, CTDs (odds ratio [OR] 2.8, 95%CI 1.3–6.0; p = 0.008), chronic obstructive pulmonary disease (OR 3.8, 95%CI 2.1–6.7; p < 0.001) and asthma onset at <20 years old (OR 1.8, 95%CI 1.1–3.2; p = 0.03) were associated with low FEV1 (defined as %FEV1 < 80%) in asthma.
Conclusions
Asthma with CTDs was related to lower lung function and low‐T2 inflammation asthma.
The aim of this study was to investigate the clinical characteristics of asthma with connective tissue diseases. Asthma with connective tissue diseases was related to lower lung function and low‐T2 inflammation asthma. |
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Bibliography: | Funding information This study was partially supported by research grants from Teijin Pharma. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Funding information This study was partially supported by research grants from Teijin Pharma. |
ISSN: | 1752-6981 1752-699X |
DOI: | 10.1111/crj.13595 |