Misconceptions About Calcimimetics

:  Calcimimetics are ligands that activate the calcium receptor. Some are small molecules and of these, the most extensively studied are phenylalkylamines like cinacalcet. This compound is a positive allosteric modulator that selectively targets the parathyroid calcium receptor to inhibit the secret...

Full description

Saved in:
Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1068; no. 1; pp. 471 - 476
Main Author NEMETH, E.F.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.04.2006
Subjects
allosteric modulators
Allosteric properties
Animals
calcimimetics
Calcium - agonists
Calcium - physiology
calcium receptor
Cloning, Molecular
drug discovery
Humans
Receptors, Calcium-Sensing - genetics
Receptors, Calcium-Sensing - physiology
Reproducibility of Results
Online AccessGet full text

Cover

More Information
Summary::  Calcimimetics are ligands that activate the calcium receptor. Some are small molecules and of these, the most extensively studied are phenylalkylamines like cinacalcet. This compound is a positive allosteric modulator that selectively targets the parathyroid calcium receptor to inhibit the secretion of parathyroid hormone. Cinacalcet is the first calcimimetic compound to attain regulatory approval for the treatment of hyperparathyroidism resulting from end‐stage renal disease. The discovery of calcimimetics and the receptor they act on are considered with the intent of extracting lessons relevant to medical research and the discovery of new drugs.
Bibliography:ArticleID:NYAS44
istex:12F63ACD70C80B08626E93CBC4C5F2881D52011B
ark:/67375/WNG-R98LGRB8-M
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1346.044