Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications

• Published in: IUBMB life Vol. 62; no. 2; p. 112
• Main Authors: Zheng, Hui, Loh, Horace H, Law, Ping-Yee
• Format: Journal Article
• Language: English
• Published: England 01.02.2010
• Subjects: Animals; Arrestins - physiology; beta-Arrestins; Binding Sites; Extracellular Signal-Regulated MAP Kinases - physiology; GTP-Binding Proteins - metabolism; Humans; Membrane Microdomains - physiology; Phosphorylation; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - physiology; Receptors, Opioid, mu - physiology; Signal Transduction - physiology

Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes th...