Agonist-selective signaling of G protein-coupled receptor: mechanisms and implications

Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes th...

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Bibliographic Details
Published inIUBMB life Vol. 62; no. 2; p. 112
Main Authors Zheng, Hui, Loh, Horace H, Law, Ping-Yee
Format Journal Article
LanguageEnglish
Published England 01.02.2010
Subjects
Animals
Arrestins - physiology
beta-Arrestins
Binding Sites
Extracellular Signal-Regulated MAP Kinases - physiology
GTP-Binding Proteins - metabolism
Humans
Membrane Microdomains - physiology
Phosphorylation
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - physiology
Receptors, Opioid, mu - physiology
Signal Transduction - physiology
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Summary:Agonist-selective signaling or ligand-biased signaling of G protein-coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes the observations of agonist-selective signaling of various GPCRs, indicating the significance of agonist-selective signaling in biological processes. In addition, current review also provides an overview on how agonist-selective signaling is initiated. Especially, the relationship between GPCR-G protein interaction and GPCR-beta-arrestin interaction is discussed in depth.
ISSN:1521-6551
DOI:10.1002/iub.293