Controlled drug delivery studies of biological macromolecules: Sodium alginate and lignosulphonic acid films

• Published in: Journal of applied polymer science Vol. 131; no. 13; pp. np - n/a
• Main Authors: Reddy, S. Giridhar, Pandit, Akanksha Saxena
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 05.07.2014; Wiley; Wiley Subscription Services, Inc
• Subjects: Applied sciences; biocompatibility; biodegradable; Biological and medical sciences; blends; drug delivery systems; Exact sciences and technology; General pharmacology; Materials science; Medical sciences; Natural polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers; Starch and polysaccharides; Biological properties; drug delivery systems; biodegradable; Polymer blends; Control release polymer; biocompatibility; Uronide polymer; Crosslinking; Drug carrier; pH effect; Alginates; Experimental study; Calcium Chlorides; In vitro; Polyelectrolyte; Crosslinked polymer; Oside polymer; Antibacterial agent; Ciprofloxacin; Release; Lignosulfonate; blends; Lignin derivatives
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.40442

ABSTRACT The ciprofloxacin (CPX)‐loaded blends made of sodium alginate and lignosulfonic acid (LS) were prepared by solution casting method in the ratio of 80/20. The blends were crosslinked for different intervals of time to control the drug release. The drug release was investigated for 24 hours in different pH medium (1, 4, 7, and 9). It was confirmed that drug release is controlled by diffusion through the polymer matrix followed by the erosion of the polymer. The pH of the surrounding medium influences the drug solubility, swelling, and degradation rate of the polymer and therefore the overall drug release process. The blend shows minimal drug release at pH 1 and 9, whereas moderate release at pH 4, but rapid release at pH 7. Further FTIR, XRD, and SEM characterization are carried, to confirm the chemical‐interaction, crystallization effects, and compatibility between the blend matrixes. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40442.