Varicocele - a case for early intervention [version 1; peer review: 3 approved]

• Published in: F1000 research Vol. 5; p. 1792
• Main Authors: Bach, Phil V, Najari, Bobby B, Goldstein, Marc
• Format: Journal Article
• Language: English
• Published: England Faculty of 1000 Ltd 2016; F1000Research; F1000 Research Ltd
• Subjects: Male Infertility; Pediatric Urology; Reproductive Endocrinology & Infertility; Review; Varicocele; hypogonadism; testosterone; microsurgery; male infertility; varicocelectomy; intracytoplasmic sperm injection; assisted reproductive technologies
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.7179.1

Testicular varicocele, which is defined as the dilation of the veins draining the testicle, has long been associated with a detrimental effect on testicular function. Despite a lack of high-quality, prospective data, recent evidence has shed light on potential links between varicocele and male infertility and serum testosterone levels. Similarly, varicocele repair has increasingly been shown to have a beneficial impact on pregnancy rates, semen parameters, and on improving serum testosterone in adult men. Numerous studies have assessed the optimal technique for varicocele repair and the bulk of the evidence has shown the microsurgical inguinal/subinguinal approach to have the highest success rates, the lowest overall complication rates, and the lowest recurrence rates. The management of varicocele in adolescents remains a clinical conundrum, but contemporary evidence suggests early deleterious effects of varicocele on testicular function in some patients. Well-designed prospective trials are critical to delineate the true impact and role of varicocele repair on male infertility and hypogonadism in adult and adolescent men.