Inverse Probability Weighted Cox Regression for Doubly Truncated Data

• Published in: Biometrics Vol. 74; no. 2; pp. 481 - 487
• Main Authors: Mandel, Micha, de Uña-Álvarez, Jacobo, Simon, David K., Betensky, Rebecca A.
• Format: Journal Article
• Language: English
• Published: United States Wiley-Blackwell 01.06.2018; Blackwell Publishing Ltd
• Subjects: Age of Onset; Biased data; BIOMETRIC METHODOLOGY: DISCUSSION PAPER; Biometry - methods; Humans; Inverse weighting; Movement disorders; Neurodegenerative diseases; Parkinson Disease - genetics; Parkinson's disease; Polymorphism, Single Nucleotide; Probability; Proportional Hazards Models; Regression Analysis; Regression models; Right truncation; Single-nucleotide polymorphism; Software; Statistical analysis; U statistic; U statistic; Biased data; Right truncation; Inverse weighting
• ISSN: 0006-341X; 1541-0420
• DOI: 10.1111/biom.12771

Doubly truncated data arise when event times are observed only if they fall within subject-specific, possibly random, intervals. While non-parametric methods for survivor function estimation using doubly truncated data have been intensively studied, only a few methods for fitting regression models have been suggested, and only for a limited number of covariates. In this article, we present a method to fit the Cox regression model to doubly truncated data with multiple discrete and continuous covariates, and describe how to implement it using existing software. The approach is used to study the association between candidate single nucleotide polymorphisms and age of onset of Parkinson's disease.