Comparison of Two Smoothing Methods for Exploring Waning Vaccine Effects

• Published in: Applied statistics Vol. 48; no. 3; pp. 395 - 407
• Main Authors: Durham, L. Kathryn, Halloran, M. Elizabeth, Longini, Ira M., Manatunga, Amita K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK and Boston, USA Blackwell Publishers Ltd 1999; Blackwell Publishers; Blackwell; Royal Statistical Society
• Series: Journal of the Royal Statistical Society Series C
• Subjects: Analytical estimating; Applications; Cholera; Cholera vaccine; Data smoothing; Datasets; Economic efficiency; Estimation methods; Evaluation; Exact sciences and technology; Immunization; Infections; Mathematics; Medical sciences; Multivariate analysis; Parametric models; Probability and statistics; Protective effects; Risk; Sciences and techniques of general use; Smoothing; Statistics; Survival analysis; Temporal dimension; Time-dependent relative risk; Vaccination; Vaccine efficacy; Asia; Bangladesh; Infection; Statistical method; Cox model; Treatment efficiency; Oral administration; Bacteriosis; Cholera; Statistical estimation; Vaccine; Medical application
• ISSN: 0035-9254; 1467-9876
• DOI: 10.1111/1467-9876.00160

We consider the statistical evaluation and estimation of vaccine efficacy when the protective effect wanes with time. We reanalyse data from a 5-year trial of two oral cholera vaccines in Matlab, Bangladesh. In this field trial, one vaccine appears to confer better initial protection than the other, but neither appears to offer protection for a period longer than about 3 years. Time-dependent vaccine effects are estimated by obtaining smooth estimates of a time-varying relative risk RR(t) using survival analysis. We compare two approaches based on the Cox model in terms of their strategies for detecting time-varying vaccine effects, and their estimation techniques for obtaining a time-dependent RR(t) estimate. These methods allow an exploration of time-varying vaccine effects while making minimal parametric assumptions about the functional form of RR(t) for vaccinated compared with unvaccinated subjects.