Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng

Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng ( P. ginseng ), as a traditiona...

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Published inFrontiers in pharmacology Vol. 14; p. 1218803
Main Authors Cao, Xinxin, Yao, Fan, Zhang, Bin, Sun, Xiaobo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.07.2023
Subjects
ginsenosides
heart disease
mechanism
mitochondria
Panax ginseng
Pharmacology
ginsenosides
mechanism
Panax ginseng
heart disease
mitochondria
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Abstract Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng ( P. ginseng ), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng .
AbstractList Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng ( P. ginseng ), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng .
Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng (P. ginseng), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng.
Heart diseases have a high incidence and mortality rate, and seriously affect people's quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. ( ), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of .
Heart diseases have a high incidence and mortality rate, and seriously affect people's quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng (P. ginseng), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng.Heart diseases have a high incidence and mortality rate, and seriously affect people's quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng (P. ginseng), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng.
Author Yao, Fan
Zhang, Bin
Sun, Xiaobo
Cao, Xinxin
AuthorAffiliation 1 Institute of Medicinal Plant Development , Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China
3 Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine , Beijing , China
4 Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease , State Administration of Traditional Chinese Medicine , Beijing , China
2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine , Ministry of Education , Beijing , China
AuthorAffiliation_xml – name: 4 Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glyeolipid Metabolism Disorder Disease , State Administration of Traditional Chinese Medicine , Beijing , China
– name: 1 Institute of Medicinal Plant Development , Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China
– name: 3 Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine , Beijing , China
– name: 2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine , Ministry of Education , Beijing , China
Author_xml – sequence: 1
  givenname: Xinxin
  surname: Cao
  fullname: Cao, Xinxin
– sequence: 2
  givenname: Fan
  surname: Yao
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– sequence: 3
  givenname: Bin
  surname: Zhang
  fullname: Zhang, Bin
– sequence: 4
  givenname: Xiaobo
  surname: Sun
  fullname: Sun, Xiaobo
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Keywords ginsenosides
mechanism
Panax ginseng
heart disease
mitochondria
Language English
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Reviewed by: Frederic Boal, Metabolic and Cardiovascular Research Institute, France
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Snippet Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function...
Heart diseases have a high incidence and mortality rate, and seriously affect people's quality of life. Mitochondria provide energy for the heart to function...
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SubjectTerms ginsenosides
heart disease
mechanism
mitochondria
Panax ginseng
Pharmacology
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Title Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng
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