Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng

Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng ( P. ginseng ), as a traditiona...

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Published inFrontiers in pharmacology Vol. 14; p. 1218803
Main Authors Cao, Xinxin, Yao, Fan, Zhang, Bin, Sun, Xiaobo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.07.2023
Subjects
ginsenosides
heart disease
mechanism
mitochondria
Panax ginseng
Pharmacology
ginsenosides
mechanism
Panax ginseng
heart disease
mitochondria
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Summary:Heart diseases have a high incidence and mortality rate, and seriously affect people’s quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. Panax ginseng ( P. ginseng ), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that P. ginseng and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of P. ginseng on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of P. ginseng .
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Reviewed by: Frederic Boal, Metabolic and Cardiovascular Research Institute, France
Feifei Guo, China Academy of Chinese Medical Sciences, China
Edited by: Guoliang Meng, Nantong University, China
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2023.1218803